Anler de Vries, a wholesale and retail distributor of sceletium, explained that a user’s mood is elevated as the mesembrine, mesembrenol and tortuosamine in the plant interact with the brain’s dopamine and serotonin receptors, which then cause a “feel-good effect”. De Vries continues, saying that “sceletium is not a controlled product, and therefore the usage, trade and possession thereof is completely legal.” “Sceletium is very potent and [even] minute quantities will give the desired effect,” explains de Vries. De Vries says, “I prefer to do only the smoker’s cut and the powder, because of the many uses between smoking and eating the product.”

De Vries explains that one can smoke sceletium by mixing the powder with the tobacco of rolled cigarettes, in the flavour of a Hubbly Bubbly, or clean through a vaporiser. “The smoke is sweet-tasting and does not irritate the lungs or throat,” says de Vries. De Vries continues to explain that the powder, although bitter in taste, can be taken orally in tea, in a spoon of honey or in yoghurt. De Vries also explains that the sceletium powder can also be used as a snuff at lower dosages.

However, de Vries explains that there are side effects to the substance, such as headaches, slight nausea, insomnia and a feeling of sedation if one overdoses on the amount of sceletium they intake. De Vries continues to say that “sceletium is non-hallucinogenic and non-addictive and can be used on a regular basis, followed by abstinence, with no effects of withdrawal”.

According to and WebMD, there have been no severe side effects reported and no confirmed reports of drug connections related to the use of sceletium. “However, because of the neuroreceptor activities of sceletium, there may be interactions with other pharmacokinetic drugs. People taking any psychiatric drugs, including all anti-anxiety drugs, sedatives, hypnotics, antidepressants, anti-psychotics, so-called designer or recreational drugs, or any cardiac medication, are advised not to take sceletium-containing products,” states


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